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The duration of the febrile period is about 10 days. Further, symptoms of Baclofen pills syndrome manifest: bleeding of the gums increases, nosebleeds, hematuria, and melena are noted. Blood pressure drops to 60 mm Hg. Art., with massive bleeding develops hemorrhagic shock. Perhaps the appearance of symptoms of CNS damage with an increase in neurological deficit (excitation, stupor, signs of encephalitis). The recovery period ranges from 2 weeks to several months.
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The most common complication is hemorrhagic shock. In severe shock, the development of multiple organ disorders (acute renal, cardiac, respiratory failure) is likely. In addition, CNS lesions of Baclofen pills nature are possible with the addition of neurological syndromes (encephalopathy, encephalitis). In vaccinated patients, transient alopecia sometimes appears after an infection. Quite often, against the background of leukopenia and damage to the capillary wall, bronchopneumonia occurs.
The most common cause of death is pulmonary edema.
In connection with the introduction of vaccination, severe forms of the course of the disease are becoming less common. If hemorrhagic fever is suspected, it is necessary to consult an infectious disease specialist with subsequent hospitalization in the patient in the intensive care unit of the infectious diseases hospital. During the physical examination, there are no specific symptoms for this viral infection.
General and biochemical study of the material.
Attention is drawn to the general intoxication syndrome, redness, swelling of the neck, face, the presence of a petechial rash, lymphadenopathy is possible. Characterized by the appearance of conjunctivitis, enanthema baclofen oral mucosa. The following clinical and laboratory methods are used in the diagnosis:
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Due to damage to the cells of the reticuloendothelial system, the presence of thrombocytopenia and leukopenia is noted in the KLA. Due to damage to the vascular wall and extravasation of the liquid part of the blood, signs of blood clotting are observed. In the general analysis of urine - proteinuria. Daily loss of protein in the urine can reach 10 g. With the appearance of multiple organ failure in the blood, the corresponding markers (AlAT, AsAT, urea, creatinine) increase. Determination of infectious agents. To detect specific antibodies, blood is taken 2 weeks after the onset of the disease.
This method is rather retrospective. Complement fixation reaction, indirect immunofluorescence reaction, hemagglutination inhibition reaction are used. To detect the virus, pharyngeal swabs, urine are examined; sampling is carried out up to 7 days from the onset of the disease. The most sensitive method for detecting a pathogen in the early stages is reverse transcription PCR.
Finding out the history of the disease, as well as comparing the data of the clinical picture with the results of the tests, allows you to establish the correct diagnosis and prescribe the appropriate treatment.
Given the relative rarity of this nosology outside of endemic areas and the nonspecificity of initial symptoms, making a diagnosis can be very difficult. Differentiation is carried out with other hemorrhagic fevers, in particular, with South American (Bolivian, Venezuelan, Brazilian). In the stage of intoxication in the absence of a pronounced hemorrhagic syndrome, it is necessary to exclude influenza, arbovirus infections, sepsis, and at the height of the disease - hemorrhagic diathesis.
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Treatment should be carried out in isolation of the patient under the supervision of an infectious disease specialist. When complications are attached, consultation of specialized specialists (neurologist, pulmonologist, nephrologist, cardiologist) may be required. Strict bed rest is required. The main method of therapy is the transfusion of convalescent plasma. This method gives the best results at the initial stages of the disease (up to 8 days).
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There are reports of positive results of treatment with ribavirin. This method is especially relevant in the absence of immune plasma. According to WHO recommendations, the drug is administered intravenously on the first day at a dose of 30 mg/kg once, then 15 mg/kg 4 times a day. 4 days and 7.5 mg/kg/day.
In parallel, symptomatic treatment is carried out with the correction of developed disorders (detoxification therapy, compensationblood volume reduction, the use of cardiovascular drugs, antipyretic drugs, correction of hemostasis disorders).
With a timely recognized disease and proper treatment, the prognosis is favorable. In the case of the development of severe forms, the duration of the Argentine hemorrhagic fever is about 11 days, and the mortality rate reaches 15%. Non-specific prevention measures include the fight against rodents in endemic areas through the use of poisonous substances and special traps.
In addition, it is necessary to use respirators in dusty work. Vaccination of local residents allows you to control the course of the disease. To date, a live attenuated vaccine is used, experimental samples are being tested. The use of ribavirin as emergency prophylaxis is not recommended. The exception is pregnant patients who have been in contact with the patient.
Argentine hemorrhagic fever is an acute viral disease related to zoonoses with natural focality. It is characterized by fever, exanthema, various severity of thrombohemorrhagic syndrome.
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