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The most common complication is hemorrhagic shock. In severe shock, the development of multiple organ disorders (acute renal, cardiac, respiratory failure) is likely. In addition, CNS lesions of Baclofen pills nature are possible with the addition of neurological syndromes (encephalopathy, encephalitis). In vaccinated patients, transient alopecia sometimes appears after an infection. Quite often, against the background of leukopenia and damage to the capillary wall, bronchopneumonia occurs.
The most common cause of death is pulmonary edema.
In connection with the introduction of vaccination, severe forms of the course of the disease are becoming less common. If hemorrhagic fever is suspected, it is necessary to consult an infectious disease specialist with subsequent hospitalization in the patient in the intensive care unit of the infectious diseases hospital. During the physical examination, there are no specific symptoms for this viral infection.
General and biochemical study of the material.
Attention is drawn to the general intoxication syndrome, redness, swelling of the neck, face, the presence of a petechial rash, lymphadenopathy is possible. Characterized by the appearance of conjunctivitis, enanthema baclofen oral mucosa. The following clinical and laboratory methods are used in the diagnosis:
Due to damage to the cells of the reticuloendothelial system, the presence of thrombocytopenia and leukopenia is noted in the KLA. Due to damage to the vascular wall and extravasation of the liquid part of the blood, signs of blood clotting are observed. In the general analysis of urine - proteinuria. Daily loss of protein in the urine can reach 10 g. With the appearance of multiple organ failure in the blood, the corresponding markers (AlAT, AsAT, urea, creatinine) increase. Determination of infectious agents. To detect specific antibodies, blood is taken 2 weeks after the onset of the disease.
This method is rather retrospective. Complement fixation reaction, indirect immunofluorescence reaction, hemagglutination inhibition reaction are used. To detect the virus, pharyngeal swabs, urine are examined; sampling is carried out up to 7 days from the onset of the disease. The most sensitive method for detecting a pathogen in the early stages is reverse transcription PCR.
Finding out the history of the disease, as well as comparing the data of the clinical picture with the results of the tests, allows you to establish the correct diagnosis and prescribe the appropriate treatment.
Given the relative rarity of this nosology outside of endemic areas and the nonspecificity of initial symptoms, making a diagnosis can be very difficult. Differentiation is carried out with other hemorrhagic fevers, in particular, with South American (Bolivian, Venezuelan, Brazilian). In the stage of intoxication in the absence of a pronounced hemorrhagic syndrome, it is necessary to exclude influenza, arbovirus infections, sepsis, and at the height of the disease - hemorrhagic diathesis.